Tirzepatide vs Semaglutide: Complete GLP-1 Comparison
Compare Tirzepatide (Mounjaro/Zepbound) and Semaglutide (Ozempic/Wegovy) for weight loss. Clinical data, side effects, and cost analysis.
Tirzepatide and Semaglutide are the two leading GLP-1 medications for weight loss and diabetes management. While both are highly effective, they differ in their mechanisms and clinical outcomes.
Quick Comparison
| Category | Tirzepatide | Semaglutide |
|---|---|---|
| Mechanism | Dual GIP/GLP-1 receptor agonist | GLP-1 receptor agonist only |
| Average Weight Loss | 20-22% body weight | 14-15% body weight |
| Brand Names (Diabetes) | Mounjaro | Ozempic, Rybelsus |
| Brand Names (Obesity) | Zepbound | Wegovy |
| FDA Approved | Yes (2022) | Yes (2017) |
| Dosing | Weekly injection (2.5-15mg) | Weekly injection (0.25-2.4mg) |
| Main Side Effects | Nausea, diarrhea, vomiting | Nausea, diarrhea, vomiting |
The Dual Mechanism Advantage
Semaglutide works by activating GLP-1 receptors, which reduces appetite and slows gastric emptying. Tirzepatide goes further by also activating GIP receptors, creating a dual-action effect. This dual mechanism appears to produce greater metabolic benefits, including enhanced weight loss and improved blood sugar control.
Making Your Decision
Both medications are effective options. Tirzepatide may be preferred when maximum weight loss is the goal, while Semaglutide has a longer track record and may be preferred by insurers. Cost, insurance coverage, and individual response should all factor into your decision. Consult with your healthcare provider to determine which is right for you.
Learn more about Tirzepatide
Read our complete Tirzepatide guide
Learn more about Semaglutide
Read our complete Semaglutide guide
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Frequently Asked Questions
Is Tirzepatide more effective than Semaglutide for weight loss?
Yes, clinical trials show Tirzepatide produces greater weight loss than Semaglutide. The SURMOUNT-5 trial found Tirzepatide users lost 20.2% of body weight vs 13.7% for Semaglutide over 72 weeks. This is likely due to Tirzepatide's dual mechanism targeting both GIP and GLP-1 receptors.
Which has fewer side effects, Tirzepatide or Semaglutide?
Both medications have similar side effect profiles, primarily gastrointestinal issues like nausea, diarrhea, and vomiting. Some studies suggest Tirzepatide may cause slightly more GI side effects at higher doses, but the difference is not significant for most patients.
Can I switch from Semaglutide to Tirzepatide?
Yes, many patients switch from Semaglutide to Tirzepatide for enhanced weight loss. Your provider will typically start you at a lower Tirzepatide dose and titrate up. Always switch under medical supervision.
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