Peptides for Sexual Health
Peptides targeting sexual function, libido, and performance through melanocortin receptor activation.
Peptides for Sexual Health
How Sexual Health Peptides Work
PT-141 (Bremelanotide) represents a different approach to sexual dysfunction treatment. Unlike medications targeting blood flow, PT-141 works through the central nervous system by activating melanocortin receptors in the brain that influence sexual desire.
Mechanism of Action
PT-141 activates melanocortin 4 receptors (MC4R) in the hypothalamus, areas of the brain involved in sexual arousal. This mechanism addresses desire rather than just physical response, making it effective for people who don't respond to traditional treatments.
Important Considerations
Before You Start
- PT-141 is FDA-approved as Vyleesi for female hypoactive sexual desire disorder
- Can be legally compounded for off-label use in men
- Common side effects include nausea and flushing
- Melanotan II is Category 2 restricted and not legal for compounding
Find Providers Offering Sexual Health Peptides
Amazing Meds
TelehealthConcierge MD
TelehealthDefy Medical
TelehealthEvolve Telemed
TelehealthHenry Meds
TelehealthHone Health
TelehealthFrequently Asked Questions
What is PT-141 and how does it work?
PT-141 (Bremelanotide) activates melanocortin receptors in the brain that influence sexual desire. Unlike Viagra which affects blood flow, PT-141 works centrally to enhance libido and arousal. It's FDA-approved for women as Vyleesi.
Is PT-141 available for men?
Yes. While Vyleesi is FDA-approved only for women, PT-141 can be legally compounded for off-label use in men. Studies show effectiveness for male erectile dysfunction, particularly in men who don't respond to PDE5 inhibitors like Viagra.
What are the side effects of PT-141?
Nausea is the most common side effect (40% of users), typically lasting 1-2 hours. Other effects include flushing, headache, and injection site reactions. PT-141 can increase blood pressure and should be used cautiously in those with cardiovascular conditions.
How is PT-141 different from Viagra?
PT-141 works in the brain to enhance desire, while Viagra works locally to improve blood flow. PT-141 can help when the issue is low libido rather than physical response. They work through completely different mechanisms and can theoretically be combined.
Is Melanotan II the same as PT-141?
No. Melanotan II is a related peptide that also activates melanocortin receptors but has additional effects including skin tanning. Melanotan II is on the FDA Category 2 list and cannot be legally compounded. PT-141 was developed from Melanotan II research.
How do I get PT-141?
PT-141 can be obtained through compounding pharmacies with a prescription for off-label use, or as brand-name Vyleesi (for women with HSDD). Find a provider who offers sexual health peptide therapy through our directory.
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