Peptides for Weight Loss
GLP-1 receptor agonists and metabolic peptides that support weight management through appetite regulation and improved metabolism.
Peptides for Weight Loss
How Weight Loss Peptides Work
Weight loss peptides have revolutionized obesity treatment. GLP-1 receptor agonists like semaglutide and tirzepatide work by mimicking natural hormones that regulate appetite and blood sugar, helping patients achieve significant, sustained weight loss.
Mechanism of Action
These peptides activate receptors in the brain that control hunger and satiety. They slow gastric emptying, making you feel full longer, and improve insulin sensitivity. The result is reduced caloric intake without constant hunger.
Important Considerations
Before You Start
- GLP-1 agonists require ongoing use to maintain weight loss
- Common side effects include nausea, especially during dose escalation
- Compounded semaglutide/tirzepatide is no longer legal since shortage resolution
- Brand-name versions (Ozempic, Wegovy, Mounjaro) cost $900-1,400/month without insurance
Find Providers Offering Weight Loss Peptides
Amazing Meds
TelehealthConcierge MD
TelehealthDefy Medical
TelehealthEvolve Telemed
TelehealthHenry Meds
TelehealthHone Health
TelehealthFrequently Asked Questions
Which peptide is best for weight loss?
Tirzepatide (Mounjaro/Zepbound) shows the highest weight loss in clinical trials at 20-22%, followed by semaglutide (Wegovy) at 15-17%. Retatrutide, still in trials, has shown up to 24% weight loss but is not yet FDA-approved.
Can I still get compounded semaglutide for weight loss?
No. The FDA declared the semaglutide shortage resolved in February 2025, making compounding illegal. You must now use brand-name Ozempic or Wegovy, which require a prescription and cost $900-1,300/month without insurance.
How long does it take to see weight loss results from peptides?
Most patients notice appetite changes within the first week. Measurable weight loss typically begins within 2-4 weeks. Clinical trials show maximum results around 68-72 weeks of continuous treatment.
Are weight loss peptides safe long-term?
GLP-1 agonists have been studied for several years with acceptable safety profiles. The SELECT trial showed cardiovascular benefits with semaglutide. However, they carry a boxed warning about thyroid tumors (based on rodent studies) and pancreatitis risk.
What happens when you stop taking weight loss peptides?
Weight regain typically begins upon discontinuation. Studies show patients regain 6-7% of body weight within one year of stopping. These medications are designed for chronic use, similar to blood pressure medications.
How do I find a provider for weight loss peptides?
Look for providers with proper medical credentials who use verified pharmacy sources. Telehealth clinics can prescribe brand-name GLP-1s with proper evaluation. Our directory lists verified providers who offer weight loss peptide therapy.
Related Research & Guides
Semaglutide Complete Guide
Everything you need to know about semaglutide for weight loss
Tirzepatide vs Semaglutide
Comparing the two leading GLP-1 medications
Retatrutide Guide
The emerging triple agonist showing 24% weight loss
GLP-1 Beyond Weight Loss
Additional health benefits of GLP-1 agonists
Related Topics
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